This is the first top-flight meeting since the 1971-72 season.
Huddersfield have lost their last seven league meetings against Leicester; their joint-longest losing run versus an opponent, along with Ipswich and Wolves.
The Terriers did, however, beat Leicester 2-1 in an FA Cup fourth-round replay at the King Power Stadium in February 2013.
Huddersfield are without a clean sheet in the last 11 meetings with the Foxes in all competitions.
Huddersfield Town

Victory would make Huddersfield only the fifth promoted team to reach at least 10 points after the opening five matches of a Premier League season.
The Terriers could become only the third newly-promoted side to keep a clean sheet in their opening three Premier League home games, emulating Swansea City (2011-12) and Watford (2015-16).
Huddersfield became the last team in this season’s Premier League to concede a goal against West Ham on Monday, after 342 minutes of action.
Both Huddersfield and Leicester have only made one change to their starting XI overall this season in the Premier League.
Leicester City

Leicester are in danger of losing four of their opening five Premier League matches for just the second time, after 1994-95. That campaign ended in relegation.
Craig Shakespeare lost just two of his opening 10 league matches in charge but has since lost five of his past seven.
The Foxes have lost 15 of their 21 away league games since the start of last season (W2, D4).
Their average possession of 36.6% is the lowest in the Premier League this season.
Jamie Vardy has been involved in 14 goals (11 goals, three assists) in 17 league appearances under Shakespeare.